Bactericidal index: a new way to assess quinolone bactericidal activity in vitro
نویسندگان
چکیده
منابع مشابه
Bactericidal index: a new way to assess quinolone bactericidal activity in vitro.
A new method of assessing the bactericidal activity of quinolones and other antibacterial agents, known as the bactericidal index or BI, is introduced and discussed. The BI represents total bacterial kill over a drug concentration range limited to levels achievable in vivo. This method allows the bactericidal activity of drugs to be readily compared. Calculation of BI produces a single value pe...
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as frequent in those with bactericidal activity (54%) as in those without (56%). The coexistence of bactericidal activity and bacteremia was reproduced and studied in experimentally infected weanling rats. Serum from such rats kills in vitro 95% of conventionally broth-grown bacteria within 10 min, but does not kill organisms obtained from the infected animals. Thus bactericidal activity as con...
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background and objectives: the most common problems limiting the medical use of aminoglycosides have been the nephro- and oto-toxicities as well as the increasing bacterial resistance. encapsulation of drugs into liposomes enhances their efficacy while reducing their toxicities. the aim of this study was to evaluate the antimicrobial activity of free and liposomal amikacin. material and method...
متن کاملIn Vitro Bactericidal Activity of Encapsulated Amikacin in Liposome
Background and Objectives: The most common problems limiting the medical use of aminoglycosides have been the nephroand oto-toxicities as well as the increasing bacterial resistance. Encapsulation of drugs into liposomes enhances their efficacy while reducing their toxicities. The aim of this study was to evaluate the antimicrobial activity of free and liposomal amikacin. Material and Methods: ...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1997
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/39.6.713